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The piperidinone also engages in the S 1 pocket, where the fluorine on the upstream side forms a hydrogen bond with Tyr631, while the fluorine on the downstream piperidine makes a hydrophobic contact with Tyr666 and Tyr662

Oncotarget 7 , 29682984 (2016)

Both are under the control of the Thy1 promoter, and the mice demonstrate overexpression of APP with levels approximately threefold higher than those endogenously expressed

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