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Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway

DATS also inhibited LPS-induced NF-B-dependent expression of COX-2, iNOS, tumor necrosis factor- (TNF-), and interleukin-1 (IL-1) (37)

Lipid nanoparticle-mediated hepatocyte delivery of siRNA and silibinin in metabolic dysfunction-associated steatotic liver disease

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Selenium appears to have a significant protective effect against the harm and dysfunction brought on by excessive activation of the HPA axis

In Alstrm syndrome, diabetes is common due to ALMS1 gene-related defects in -cell function and peripheral insulin signaling (129)