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Cardiovascular Outcomes Following Ertugliflozin Treatment in Type 2 Diabetes Mellitus Participants with Vascular Disease (VERTIS-CV), which compared ertugliflozin with placebo showed non-inferiority in regards to its primary MACE outcome, as well as a 30% reduction in HHF [41]

The GRADE approach assessed the quality of the evidence for each outcome across five domains: risk of bias, inconsistency, indirectness, imprecision and publication bias