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Abbreviations 4-HNE: 4-Hydroxynonenal ACSL4: Acyl coenzyme A synthetase long-chain family member 4 AD: Alzheimers disease ADSCs: Adipose-derived mesenchymal stem cells ALI: Acute liver injury ALS: Amyotrophic lateral sclerosis BBB: Blood-brain barrier BMSCs: Bone marrow mesenchymal stem cells DMT1: Divalent metal transporter 1 dNCR: Delayed neurocognitive recovery DPSCs: Dental pulp stem cells ECM: Extracellular matrix ESCRT: Endosomal sorting complexes required for transport EVs: Extracellular vesicles Exos: Exosomes Fer-1: Ferrostatin-1 FSP1: Ferroptosis suppressor protein 1 GPx: Glutathione peroxidase GPX4: Glutathione peroxidase 4 GSH: Glutathione HO-1: Heme oxygenase-1 HucMSCs: Human umbilical cord mesenchymal stem cells ILVs: Intraluminal vesicles IRI: Ischaemia-Reperfusion injury MDA: Malondialdehyde miRNAs: microRNAs MSCs: Mesenchymal stem cells MTTP: Microsomal triglyceride transfer protein MVBs: Multivesicular bodies NCOA4: Nuclear receptor coactivator 4 ncRNAs: Non-coding RNAs NETs: Neutrophil extracellular traps Nrf2: Nuclear factor-erythroid 2 related factor 2 OA: Osteoarthritis PD: Parkinsons disease PUFA: Polyunsaturated fatty acids ROS: Reactive oxygen species SLC7A11: Solute carrier family 7 member 11 SRSF1: Serine arginine-rich splicing factor 1 STEAP3: Six-transmembrane epithelial antigen of prostate 3 HuSCs: Human urine-derived stem cells References Dixon SJKM, Lemberg MR, Lamprecht, et al

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AM optional Phase Aggressive Weeks 8-16+ CJC-1295 200 mcg Ipamorelin 200 mcg Frequency 2x daily Timing AM fasted + pre-bed Stay fasted at least 2 hours before and 30 minutes after each CJC/Ipa shot

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Cells were finally washed three times using 1X PBS and were mounted on glass slides in Dako containing 0.1 g/mL Hoechst 33342 (Sigma-Aldrich)

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