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These include: Nausea (very common, may affect more than 1 in 10 people) Diarrhoea (very common) Vomiting (common, may affect up to 1 in 10 people) Constipation and abdominal pain (common) Decreased appetite (very common) These gastrointestinal symptoms typically diminish over time as the body adjusts to the medication

and enhanced immune tolerance (196, 197)

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however, further studies are mandatory to prove the efficacy and to study the pharmacodynamic effects (Ma et al

This limits titration options and may not provide sufficient dose for patients who require higher amounts

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