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How to convert from oral estradiol to a patch Oral and transdermal estradiol aren't milligram-equivalent because oral estradiol undergoes extensive first-pass metabolism in the liver

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AKT also phosphorylates the pro-apoptotic and anti-proliferative transcription factor FOXO1, which leads to its exclusion from the nucleus and cytosolic degradation, thereby connecting tumor cell metabolism with cell cycle progression and survival

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