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Binding mechanism: Unlike peptides that bind to both the ECD and TMD, small-molecule agonists primarily interact with an allosteric binding site within the TMD

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Journal of Clinical Biochemistry and Nutrition, 67(3), 307-316

This reduced binding may affect its bioavailability and interactions with target tissues in experimental models

By conjugating nanomaterials with ligands that recognize these unique bacterial markers, researchers can ensure that the nanomaterials selectively bind to and disrupt harmful bacteria without affecting healthy microorganisms