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However, it is worth noting that most preclinical studies do not incorporate a dose titration phase, a gradual increase to the therapeutic maintenance dose, which is standard in clinical settings

If a patient depends only on appetite suppression, maintenance may become difficult when appetite changes or medication access changes

Patients should only use GLP-1 medications prescribed by licensed healthcare providers and obtained through legitimate pharmacies, ensuring product authenticity and appropriate medical supervision

A phase 2 trial assessing different doses of bimagrumab (up to 30 mg/kg) in combination with semaglutide as obesity treatment is ongoing (NCT05616013)

Possible side effects include nausea, bloating, lightheadedness, and dehydration, especially early in treatment

10.34172/apb.43672 94 ZhengZ.ZongY.MaY.TianY.PangY.ZhangC.et al (2024)