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Clinical guidelines and trial data consistently show that GLP-1 treatment delivers optimal results with sustained, long-term use typically 12 months or longer

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But in practice the scientists had to test out a number of different linker molecules, and chemically modify the GLP-1 structure slightly, in order to get the new drug to work

The combined effect may increase nausea, dizziness, or fatigue , especially in the first few weeks of treatment

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People starting tirzepatide who also have migraines should track their headache patterns carefully