Shklar and coworkers (173) examined the effects of methotrexate on hamster buccal pouch carcinomas generated by 9,10-dimethyl-l,2-benzanthracene and found that the methotrexate-treated group reported tumors that were larger and more anaplastic and that they progressed more quickly than the control group
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However, how quickly this happens depends on carnitine availability inside the muscle
Serious risks are less common but include pancreatitis and, based on animal studies, a theoretical risk of thyroid C-cell tumors, which is why GLP-1 medications are contraindicated in patients with a personal or family history of medullary thyroid carcinoma
