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The procedure is relatively painless, as most practitioners utilise a topical numbing solution before administering the treatment and results should be visible from 24 hours after injection

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The peptide cannot be obtained through normal pharmaceutical channels

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Randomization and blinding Participants were randomized in a 3:2 ratio to receive once-daily orforglipron (36 mg or MTD of 24 or 36 mg), or placebo, using a computer-generated random sequence from a Lilly interactive web response system