Choose Health is preparing to publish a clinical outcomes report in mid-2026 drawing on data from over 150,000 at-home blood tests
Table of Contents The Big Picture: Trial-Level Data Week 1: Initial Response Weeks 2-4: Scale Starts Moving Months 1-3: Significant Changes Months 3-6: Peak Efficacy Window Months 6-12+: Maintenance Phase Factors That Affect Results By Use Case: Different Timelines When to Adjust Protocol Related Reading References The Big Picture: Trial-Level Data Before diving into the weekly breakdown, here is what the SURMOUNT-1 trial showed at key timepoints (at the 15mg dose) (1): For a person starting at 220 lbs (100 kg), that translates to roughly 22 lbs lost by week 12, 35 lbs by week 24, and nearly 50 lbs by week 72
For me, the concern is around how this type of rebound effect leads to learned helplessness, a mental state in which a person gets conditioned to believe they cant control or change a situation, so they stop trying even when opportunities for change are available
The bad news is you still have to get through the side effects, even if they are short-lived
Amylyx co-CEOs Justin Klee (L) and Josh Cohen Amylyx, searching for post-ALS future, licenses a GLP-1 drug Several months after a major trial setback forced Amylyx Pharmaceuticals to pull its only approved drug from the market, the company is diving into the Sign up to read this article for free
Outside of that, were excited about bringing our innovative portfolio to India
