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Will Phase II testing require specific sandbox environments

It is a reasonable precaution, not a strict requirement

In populations who cannot exercise due to frailty, physical disability, or cardiovascular limitations, MOTS-c represents one of the most compelling candidates in the emerging class of pharmacological exercise mimetics

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It is metabolized hepatically and excreted renally, with a half-life of under thirty minutes

e-f , ALT and AST liver damage serum markers (n = 6 for Control, n = 9 for GGsTop) (e) and percent change in body weight (n = 10 per group) (f) in mice treated bi-daily with vehicle (saline) or 5 mg/kg i.p