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Think of the GLP-1 and GIP components as turning down the appetite dial while the glucagon component simultaneously turns up the metabolic furnace

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Morning vs Night: What the Comparative Data Actually Shows A 2019 study comparing GH secretagogue timing in healthy adults found that nocturnal administration (defined as within 60 minutes of sleep onset) produced mean peak GH levels of 18.4 ng/mL, compared to 7.2 ng/mL for morning administration (within 30 minutes of waking)