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The primary mechanisms involve the following: Appetite Regulation Sema has been shown to influence appetite control centers in the brain, particularly within the hypothalamus

The trial was stopped early for efficacy following a prespecified interim analysis triggered in October 2023 when two-thirds of the total planned number of primary outcome events had occurred

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doi: 10.1080/2331205X.2019.1582400 79

Hildorf S, Cortes D, Gl M, Dong L, Kristensen SG, Jensen CFS, Clasen-Linde E, Fedder J, Andersen CY, Hoffmann ER, Snksen J, Fossum M, Thorup J

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