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Three specific conditions qualify for Tier 2 (BMI 30 or higher): (1) heart failure with preserved ejection fraction (HFpEF), (2) uncontrolled hypertension despite treatment with two or more antihypertensive medications (systolic over 140 or diastolic over 90), and (3) chronic kidney disease stage 3a or higher (estimated GFR below 60)
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rodentium ( Figure 1C-E )
The genetic-baseline question most checklists skip One question that rarely appears on standard "ask your doctor" lists but increasingly should: do you offer a genetic baseline that informs my dose and titration before week one
There is no robust clinical evidence that any dietary approach causes meaningful weight loss without an underlying energy deficit
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