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More future-facing interest: researchers tend to be most excited by compounds that expand the mechanism rather than simply optimize a known one

GLP-1 RAs improve CV outcomes, as well as secondary outcomes such as progression of renal disease, in patients with established CV disease or chronic kidney disease (CKD)

Reactive astrocytes protect the CNS by releasing neurotrophic factors (for example, NGF, TGF-, LIF and BDNF) and cytokines that promote neuronal survival and create an anti-inflammatory environment 46,47

Suspected side effects should be reported via the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk)

Supplements should not replace skincare routines

Supplements That Increase GLP-1 In addition to nutrient-rich whole foods, certain supplements have shown potential to increase GLP-1 levels: Berberine Berberine is extracted from the Barberry (Berberis vulgaris ) shrub containing evergreen and deciduous plants