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3 Host-NTHi competition for haem-iron Iron is an essential micronutrient for pathogen and host alike, with critical roles in many vital cellular processes, both as an inorganic ion and through incorporation into haem, which is a molecule composed of a protoporphyrin IX (PPIX) ring and a single central iron atom (Parrow et al., 2013

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By contrast, lactylation of LSD1 in melanoma promotes its interaction with FosL1, resulting in repression of TFRC-mediated iron uptake and thereby conferring resistance to ferroptosis (70)