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In a Phase II study reported in 2024 involving 168 patients with NASH, moderate to advanced fibrosis (F2F3), and NAS 4, a significantly greater proportion of patients in the denifanstat group achieved the primary endpoint compared with placebo, with statistically meaningful improvements in fibrosis as well

And there can be side effects from treatment

Common Actives GHK-Cu in studies outperformed tretinoin and vitamin C in procollagen synthesis, demonstrating a 70% response rate compared to 50% for vitamin C and 40% for tretinoin

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Extracted proteins were removed from the dialysis casing into 1.5-ml Eppendorf tubes, and concentration was measured with Pierce BCA Protein Assay Kit (23225