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Consequently, changes in the activity of key enzymes in the glycolytic pathway significantly affect lactate production and, thus, lactylation levels

Age (Dordr.) 2013;35:15311544

A novel miR-338-3p/SLC1A5 axis has been identified as a key regulator of oxidative stress-induced ferroptosis in DR: high glucose significantly upregulates miR-338-3p expression in RPE cells, and miR-338-3p silencing reverses RPE cell death and ferroptosis ( Although studies have confirmed that the three components form a positive-feedback loop that drives DR progression and that antioxidant therapy can alleviate DR pathology, the key molecular triggers that initiate the loopsuch as the cell-specific mechanisms by which hyperglycemia induces excessive ROS production in different retinal cellsremain poorly defined

The pH of the film's surface should be 7 or nearly neutral

Lysis was achieved by incubating on a rotating wheel at 25 r.p.m

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