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(1s)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile 12

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CLOCK and BMAL1/ARNTL disruption is implicated in inflammation, mitochondrial dysfunction, dopamine, and serotonin disturbance in BD patients [36, 168], as well as in iron dysregulation [169]

This was achieved by inhibiting bone resorption through an increase in the OPG/RANKL ratio and promoting bone formation by enhancing the expression of osteoblast-specific transcription factors