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Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study

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On these 7 patients, 5 were fully responders while two patients have a good response in term of intensity of the crisis, but the number of crisis did not diminish significantly at the end of their crises

doi:10.1080/14737140.2017.1335199

NC is attributed to a wide range of conditions including obstructive, infectious, metabolic, and genetic causes with variable incidence