The speculated interaction between thymosin beta-4 and G-actin is believed to inhibit the polymerization process, known as actin sequestration
TB-500 is frequently dosed in larger loading amounts up front and lower maintenance amounts later, so saving the setup avoids re-deriving the units each phase
Most commercial products (including Hospira 30 mL vials, the standard used in research) carry a 23 year expiration from manufacture
Consistently, the motor nerve conduction study confirmed the absence of demyelinated processes in the tail caudal nerves after spinal cord injury (the CMAP showed normal biphasic potentials, similar amplitudes, and similar conduction velocities in all of the rats) (Table 4)
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Potential adverse effects identified by the FDA include heart toxicity, infections, pancreatitis, increased or decreased insulin sensitivity, serious immunoresponses, melanoma and death