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3.4 Se and thyroid tumors The incidence of thyroid cancer has been on the rise in the past decades, increasing faster than any other cancer (70, 71)

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Fifth, rapid gingival crevicular fluid turnover shortens local drug retention, while the periodontitis microenvironment degrades protein/peptide drugs and small-molecule inhibitors, reducing stability and bioavailability (117, 118)

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IGF-1 LR3 (Insulin-like Growth Factor 1 Long R3) is an 83-amino-acid synthetic variant of human IGF-1, engineered with two key structural modifications: a glutamic acid substitution for arginine at position 3 (R3) and a 13-amino-acid N-terminal extension peptide