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PMID: 34115284 Mol DiversStructure-activity relationship study of DEL-22379: ERK dimerization inhibitors with increased safety

The STAT6-ANGPTL4 axis may be directly or indirectly associated with activation of the cGAS-STING pathway, macrophage polarization, and macrophage-to-mesenchymal transition in the diabetic kidney, thereby promoting renal fibrosis

Both were conducted in patients who had type 2 diabetes as well as lupus, which is the population in which these drugs were being prescribed

Brand-name options may include Ozempic, Wegovy, Mounjaro, or Zepbound, depending on indication and availability

Second, larger vials (10-20 mg) generally get the same 2 mL to keep concentration high enough that GLP-1 weekly doses don't require uncomfortably large injection volumes

2022;186:R93-111