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Also, decreased glutathione levels caused motor neuron degeneration in the hSOD1 wt over-expressing mice model (hemizygous mice over-expressing wild-type hSOD1 at moderate levels) (Killoy et al., 2018) and accelerated motor neuron death in SOD1 G93A mice (Pehar et al., 2014)

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Further analysis of key immune signaling pathways, such as the IFN- pathway ( Figure 8H ) and CCL signaling pathway ( Figure 8I ), revealed crucial cell-cell interactions involving CD8 + T cells, monocytes, and NK cells within the RA immune network

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