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Both medications were initially developed to treat type 2 diabetes, but clinical results showing dramatic weight reductions sparked their evolution into tools for obesity management

Psychiatry 36 JensenC

Semaglutide, the active ingredient in Ozempic and Wegovy, and tirzepatide, the active ingredient in Mounjaro and Zepbound, have shifted this paradigm

doi: 10.3390/nu13010062 [DOI] [PMC free article] [PubMed] [Google Scholar] 41.Gianmoena K Gasparoni N Jashari A, et al

Additionally, the degree of appetite reduction may plateau or diminish slightly over time as physiological adaptation occurs, though clinical efficacy generally persists with continued use

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