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The approach depends on how many days have elapsed since the scheduled injection

Diabetes Res Clin Pract 2011;92:e1

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To counter this constant evolution, seasonal vaccines are redesigned annually on predictions of what will be the dominant circulating variants in the upcoming flu season. Predictions must be made significantly ahead of time owing to the time needed to manufacture sufficient doses of vaccine, which can lead to mismatches between vaccine and circulating strains that almost universally lead to limited efficacy

No.S1420144 CAS