ACE inhibitors and their interaction with systems and molecules involved in metabolism
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The application of antioxidant therapies aimed at lowering AGE could be a helpful tool because high AGE concentrations harm vascular smooth muscle and adversely affect NO function, which in turn impairs endothelial relaxation and prevents NO action against plaque formation from the oxidized form of LDL (Saleh, 2015)
de Sa Junior PL, Camara DAD, Porcacchia AS, Fonseca PMM, Jorge SD, Araldi RP, Ferreira AK
Humans express eight distinct glutathione peroxidase genes identified as GPX1GPX8
Environ Health Perspect 116(1):2631