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Because of this, many health experts in Europe now see obesity as a long-term disease that often needs medical treatment

Mirzaei H, Masoudifar A, Sahebkar A, Zare N, Sadri Nahand J, Rashidi B, Mehrabian E, Mohammadi M, Mirzaei HR, Jaafari MR

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Clinical evidence from GLP-1 weight loss trials does not exclude gallstone patients outright, but most protocols require baseline ultrasound screening and physician clearance

this might be attributed to the observed alleviation of oxidative and inflammatory stressful conditions induced by MTX