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however, they not only affect cancer cells but also impact normal proliferating cells

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For example, research has shown that chemotherapy agents can promote hypoxia in the TME, which drives the activation of hypoxia-inducible factors (HIFs), in particular HIF-

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Taken together, the experimental findings discussed above reveal a complex interplay between alcohol-induced zinc deficiency and two fundamental signaling pathways that are required for strong host immune capacity within the alveolar macrophages

2022;36(13-15):1023-1036.[DOI] 194