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For suspected macro-B12, precipitation with PEG is the test most often reached for, though it is nonspecific and can remove B12 that is fully available to cells, so direct measurement of the binding proteins, haptocorrin and transcobalamin, may be more informative when it is available

[111] The microbiological assay has been the most commonly used assay technique for foods, utilizing certain vitamin B 12 -requiring microorganisms, such as Lactobacillus delbrueckii subsp

A favorable check-in can still include nausea, fatigue, or injection-site reactions

Hydroxocobalamin has relatively few major drug interactions

However, many factors can limit or even prevent proper absorption

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