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Despite the prevalence of adolescents with PCOS, diagnosing and treating it has remained difficult due to its complex symptomology and the multidisciplinary nature of managing the condition

10.1016/j.cell.2017.09.021 Cell 207 StoneN

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Tirzepatide for MASH with fibrosis 15 mg produced a large majority disease-resolution rate versus a small placebo rate: Loomba NEJM 2024 (SYNERGY-NASH)

Werden SGLT-2-Inhibitoren nicht vertragen oder besteht eine Kontraindikation oder die eGFR ist nicht mehr ausreichend, sollten an ihrer Stelle GLP-1 RA eingesetzt werden

8 Compared with placebo, once weekly tirzepatide significantly reduced the combined risk of cardiovascular death or worsening HF events (hospitalisation or an urgent hospital visit requiring intravenous therapy)