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[DOI] [PubMed] [Google Scholar] 63.Nasyrova R.F., Sivakova N.., Lipatova L.V., Ivashchenko D.V., Sosina K.., Drokov .P., Shnayder N.

The rationale behind requiring a prescription for B12 injections stems from safety and regulatory concerns

In particular, amino acids such as tryptophan, phenylalanine, valine and glutamine help to stimulate GLP-1 production

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While these findings represent the most robust evidence to date for GLP-1 RA therapy in MC4R -deficient obesity, they derive from an exploratory analysis not pre-specified as a primary endpoint, and confirmation in prospective, dedicated trials is warranted