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Moreover, several animal studies highlight crosstalk between the gut microbiome and GH/IGF-1 axis and its impact on growth and metabolic disorders

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This suggests the dual mechanism might provide additional appetite control beyond GLP-1 alone

medical societies, offering structured approaches to follow up care, lifestyle planning, and long term weight management

For instance, a randomized controlled trial published in the "Journal of Clinical Endocrinology & Metabolism" found that individuals treated with GLP-1 receptor agonists experienced greater weight loss compared to the control group