Many of the one-star reviews for Henry Meds are about the lack of effectiveness of the oral meds
The reduction in AUC after oral administration can result from numerous mechanisms including: pH or bacterial-mediated metabolism of the drug within the GI tract, incomplete drug absorption from the GI tract, metabolism within the GI epithelium (which contains CYP3A4), excretion back into the GI tract by P-glycoprotein in the GI epithelium, hepatic metabolism, or biliary excretion into the GI tract
The fee includes medical history review and phone consult by a medical doctor, dosing regimen, first vial and injection supplies, initial instruction session and ongoing nursing support
As you can see, the results are dramatic and impressive
10.1038/s41586-019-1170-y 138 WangZ.DingY.WangX.LuS.WangC.HeC.et al (2018)
The trade-off is simplicity versus needle-free