Different activity of the oxidative PPP in macrophages contributes to the functional discrepancy of macrophages
Manufacturers are responsible for ensuring their products safety, but the FDA can only intervene after harmful products reach consumers
Notably, NAD + levels were not determined in this study 330
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J Clin Pharm Ther 2003;28:289-94
Abbreviations ACCase acyl-CoA carboxylases ACP acyl carrier protein ADC antibody-drug conjugate antiSMASH antibiotics and Secondary Metabolite Analysis Shell AT acyltransferase BAC bacterial artificial chromosome BAGEL BActeriocin GEnome mining tool BGC biosynthetic gene cluster BiG-FAM Biosynthetic Gene Cluster Filies Database Big-SCAPE Biosynthetic Gene Similarity Clustering and Prospective Engine BiG-SLICE Biosynthetic Genes Super-Linear Clustering Engine BiGCARP Biosynthetic Gene Convolutional Autoencoding Representations of Proteins BiLSTM Bidirectional Long Short-Term Memory BLAST Basic Local Alignment Search Tool CAPTURE Cas12a-Assisted Precise Targeted cloning Using in vivo Cre-lox REcombination CATCH Cas9-Assisted Targeting of CHromosome segments CD conserved domain CDPS cyclodipeptide synthase CLEAN Contrastive Learning-enabled Enzyme Annotation CMGnet Conditional Molecular Generation net CNN convolutional neural networks CONKAT-Seq Co-Occurrence NetworK Analysis of Targeted SEQuences CORASON Core Analysis of Syntenic Orthologues to prioritize Natural product gene clusters COSMIC Confidence of Small Molecule Identifications CRAGE Chassis-independent Recombinase-Assisted Genome Engineering CRF conditional random fields CRISPRa CRISPR activation CRISPRi CRISPR interference CCR crotonyl-CoA reductase/carboxylase CSA Composite Spectra Analysis CVD cluster variation database DAFdiscovery Data-Fusion-based Discovery DBTL design, build, test, and learn ddTAG Dynamic Degradation of triacylglycerol (TAG) DMAPP dimethylallyl pyrophosphate DMAT dimethylallyl tryptophan synthase DUF domains of unknown function ER endoplasmic reticulum FAC fungal artificial chromosomes FACS fluorescence-activated cell sorting FAS fatty acid synthase FBMN Feature-Based Molecular Networking FPP farnesyl pyrophosphate FPPS farnesyl pyrophosphate synthase FRET fluorescence resonance energy transfer FRIGG Fungal Resistance Gene-directed Genome Mining FSD flanking subdomain FunARTS Fungal bioActive compound Resistant Target Seeker GCF gene cluster families GECCO GEne Cluster prediction with COnditional random fields GFP green fluorescent protein GIPMA Global Intensity-guided Peak Matching and Alignment GNN graph neural network GNPS Global Natural Products Social GPP geranylgeranyl pyrophosphate GRAS Generally Regarded as Safe HAT histone acetyltransferase HDAC histone deacetylase HiTES high-throughput elicitor screening HMM hidden Markov model HP hypothetical protein HSQC heteronuclear single quantum coherence IDSL-MINT Mass-INTerpreter IMS imaging mass spectrometry IPK isopentenyl phosphate kinase IPP isoprenyl pyrophosphate IUP Isopentenol Utilization Pathway KGMN Knowledge-Guided Multilayer Network KS ketosynthase LAESI-MS laser-ablation-coupled electrospray ionization MS MAA mycosporine-like amino acid MassQL Mass Spec Query Language MASST Mass Spectrometry Tool MD molecular dynamics MEP methylerythritol phosphate MEV mevalonate MFS major facilitator superfamily MIA monoterpene indole alkaloid MIBiG Minimum Information about a Biosynthetic Gene cluster ML machine learning MN molecular network MNIO multinuclear iron oxygenase MS mass spectrometry NHEJ non-homologous end joining NLP natural language processing NMR nuclear magnetic resonance spectroscopy NRP nonribosomal peptide NRPS nonribosomal peptide synthetase ORF open reading frame OSMAC one strain many compounds PAM phenylalanine aminomutase PDB precursor directed biosynthesis PDB precursor-directed biosynthesis PEARL PEptide Aminoacyl-tRNA Ligase PKS polyketide synthase PLP pyridoxial-5-phosphate PoTeM polycyclic tetramate macrolactam PRISM Prediction Informatics for Secondary Metabolomes PROTAC proteolysis-targeting chimera PTM post-translation modification RF random field Rg3m Resistance Gene-Guided Genome Miner RiPP ribosomally synthesized and post-translationally modified peptide RODEO Rapid ORF Description and Evaluation Online RRE RiPP precursor recognition element SAM S-adenosylmethionine SAR structure-activity relationships SCORE-metabolite-ID Semi-automatic correlation analysis for reliable metabolite annotation SGMNS Structure-Guided Molecular Networking Strategy SHY Statistical HetereoSpectroscopy SMART Small Molecule Accurate Recognition Technology SMURF Secondary Metabolite Unknown Regions Finder SNAC synthetic diketide S-N-acylcysteamine SNAP-MS Structural similarity Network Annotation Platform for Mass Spectrometry SRE self-resistance enzyme SSN sequence similarity network STOCSY statistical total correlation spectroscopy SVM support vector machine TAR transformation-assisted recombination TC terpene cyclase TE thioesterase THIQ tetrahydroisoquinolines TRY high titer, rate, and yield TS terpene synthase UHPLC-HRMS ultra-high-performance liquid chromatography-high resolution mass spectrometry XU eXchange Unit XUC eXchange Unit between Condensation domains XUT eXchange Unit between Thiolation domains Biographies Kaushik Seshadri , born in 2001, received his undergraduate degree in Chemical Engineering from the Department of Chemical and Biomolecular Engineering at the University of California, Berkeley, in 2023
