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2-Methylbutyryl-CoA can also be converted to its carnitine derivative, 2-methylbutrylcarnitine (2MBC) via the action of carnitine O -acetyltransferase encoded by the CRAT gene

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35,36 While the subsequent GUIDE-HF trial did not find a difference in cardiovascular outcomes using PA pressure monitoring, a newly published trial based out of Europe, MONITOR-HF, demonstrated findings similar to the earlier CHAMPION trial that PA pressure monitoring to guide HF management reduced HF-related hospitalizations and improved quality of life

S2CID 7488757

Serna-Higuita LM, Isaza-Lpez MC, Hernndez-Herrera GN, et al