Most studies were conducted in Europe and Asia, and most reported outcomes after 6 months of treatment
All authors contributed to drafting the manuscript and commented on previous versions of the manuscript
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Hyperinsulinemia and insulin-like growth factor signaling promote epithelial proliferation, inhibit apoptosis, and foster a pro-inflammatory microenvironment within the colon
Contraindications:: Patients with a personal or family history of medullary thyroid carcinoma (based upon animal data - see FDA Warning) History of hypersensitivity to semaglutide or any of its excipients (serious reactions including angioedema & anaphylaxis have been reported) Side Effects: GI Adverse events: nausea, vomiting, constipation, diarrhea (~5-15%) most GI side side effects occur during dose initiation or escalation and wane after a few weeks (Drucker, 2024)
Patients who suffered injuries from off-label use may have legal options against both drug manufacturers and negligent prescribers
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