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14 After escaping from endosomes, the next challenge is transporting NADs quickly and effectively to the nucleus or specific organelles

The sublingual route allows the medication to bypass the digestive system, which can improve absorption

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ADVERSE REACTIONS ] Table 13: Glycemic Parameters at Final Visit (24-Week Study) for Sitagliptin as Add-on Combination Therapy with Metformin Immediate-Release and Insulin* Maintenance Of Sitagliptin During Initiation And Titration Of Insulin Glargine A total of 746 patients with type 2 diabetes (mean baseline HbA1C 8.8%, disease duration 10.8 years) participated in a 30-week, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of continuing sitagliptin during the initiation and uptitration of insulin glargine