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These medications have gained significant attention for their effectiveness in helping individuals achieve their weight loss goals by mimicking the action of a hormone that regulates appetite and insulin secretion

doi: 10.1038/ismej.2014.14 209 RequeP

However, retatrutide shows a higher overall rate of side effects and produces a more pronounced dose-dependent increase in heart rate due to glucagon receptor activation

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however, consistent with other weight loss approaches, a substantial portion of total body weight loss is due to lean mass loss