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Furthermore, all experiments were carried out under blind protocol, and the effect was assessed by examiners who were completely unaware of the given protocol

Despite the enrichment of several hair growth-related pathways, we focused on validating the Wnt/-catenin pathway due to its established role in hair follicle biology, the specific enrichment of canonical Wnt signaling, and the strong representation of its target genes

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632 Di-Huang-Yin-Zi effectively decreases ROS and MDA levels in prefrontal cortex, increases the expression of ferroptosis-related markers GPX4 and SLC7A11 and, and decreases iron deposition, thereby improving depressive symptoms and synaptic ultrastructure of cortical regions in post-stroke depressed (PSD) rats, suggesting that Di-Huang-Yin-Zi can reduce the symptoms and enhance function in PSD rats by inhibiting ferroptosis through SLC7A11/GPX4 pathway

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In contrast, other meta-analyses have found no significant change in HDL levels in response to IF [23, 32]