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Not so relevant in an acute stroke context due to its accessibility and time consumption, positron emission tomography scan allows the determination of BBBP by the uptake of tracers radiolabeled with short-lived positron-emitting isotopes with a lower spatial resolution compared with MRI but with higher sensitivity (174, 175)

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Numerous data from in vitro and in vivo studies, epidemiological studies, and occupational health studies have shown the toxicity of NPs

2.5 Quality assessment and risk of bias In line with PRISMA guidelines, the assessment of methodological quality was conducted to evaluate the strength of evidence, recognising that methodological limitations may introduce bias