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Occurrence of nausea, vomiting and diarrhoea reported as adverse events in clinical trials studying glucagon-like peptide-1 receptor agonists: A systematic analysis of published clinical trials

Although the exact mechanisms by which the coordinated actions of GLP-1 receptor agonism and NMDA receptor antagonism correct metabolic diseases await further elucidation, the extensive alterations in transcriptomic and proteomic responses within the hypothalamus, linked to glutamatergic signalling and synaptic plasticity, imply that the conjugate might elicit neurostructural changes in GLP-1-receptor-expressing neurons

Charo C, Holla V, Arumugam T et al

Both OASIS 4 and the earlier OASIS 1 trial of oral semaglutide reported dysaesthesia

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Furthermore, a 2026 review published in BMJ Medicine found that people taking GLP-1 medications regained weight significantly faster than those who had lost weight through diet and exercise alone