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The diversion of holotranscobalamin to the bone marrow or the urine depletes the liver, brain, and other tissues of vitamin B12, thus exacerbating neurological manifestations of deficiency and elevations of homocysteine and MMA in the blood

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Supplements cannot be titrated based on individual genetics

Patients who implement comprehensive lifestyle changes typically experience earlier and more pronounced benefits

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AHK-Cu primarily influences growth factor signaling pathways, particularly those involved in angiogenesis and hair follicle cycling