Early studies showed that growth hormone did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed sulfation factor, which later became known as somatomedin
According to the clinical expert consulted by CADTH, patients likely to demonstrate a clinically meaningful response to mecasermin include those with SPIGFD due to a genetic defect of the GHIGF-1 pathway, those who show biochemical evidence of inappropriate GH receptors, and those who have GH antibodies or GH resistance
Testing is critical, as research shows that 50% of obese men are testosterone deficient, with strong data linearly correlating testosterone levels to waist size, Shah noted
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Mecasermin is the compound a 503A or 503B compounding pharmacy can dispense and only with a prescription and a clinical indication
October 10, 2022
