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However, they have a high frequency of Th17 cells in the gut, similar to that of R161H-WT mice, and the transfer of activated T cells into naive wild type (WT) mice can induce uveitis

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and it may lead to stress reactions

[4] Importantly, NICE guidance (NG49) does not currently recommend GLP-1 receptor agonists for the treatment of NAFLD outside clinical trials, and they are not licensed for this indication in the UK