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Although there is no direct evidence at present to indicate whether metformin has anti-manic properties, these studies demonstrate that activation of the AMPK branch of the CaMKK2 signalling pathway can ameliorate depressive behaviours

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More than 36 cell types possess the VDR and interestingly paracrine production of calcitriol occurs in more than ten extrarenal organs [141]

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Jing, C., Wu, Y., Zhang, Y., Zhu, Z., Zhang, Y., Liu, Z., et al

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Kashima Y, Miki T, Shibasaki T, Ozaki N, Miyazaki M, Yano H et al

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Immunomodulatory effects of probiotics on COVID-19 infection by targeting the gut-lung Axis microbial Cross-talk

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doi: 10.1038/ijo.2013.149, 69

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