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Activation (roughly weeks 1-4): once-daily dosing at the documented per-vial amount

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In addition, on the peripheral blood smear, macrocytes and hypersegmented polymorphonuclear leukocytes may be seen

More commonly tied to cagrilintide than tirzepatide

Severe or blood glucose confirmed symptomatic hypoglycemia (glucose of 56 mg/dL or less) occurred in 6.5% and 10.4% of patients when semaglutide 0.5 mg and 1 mg, respectively, when coadministered with a sulfonylurea