Weekly subcutaneous doses start low
Some people gain a few pounds quickly because creatine pulls water into the muscles
Concurrent use of other medications known to promote weight gainsuch as certain antidepressants (particularly mirtazapine and some selective serotonin reuptake inhibitors), antipsychotics, corticosteroids, beta-blockers, or insulinmay counteract semaglutide's weight-reducing effects
Reduced hunger suppression, increased food cravings, or a return to previous eating patterns also suggest receptor desensitization
These factors contribute to the high prevalence of obesity but are not fully addressed in existing tirzepatide trials
Melanin is produced by specialized cells called melanocytes, and its overproduction can lead to hyperpigmentation and uneven skin tone